Coordinated reset neuromodulation for Parkinson's disease: Proof-of-concept study
Identifieur interne : 000A24 ( Main/Exploration ); précédent : 000A23; suivant : 000A25Coordinated reset neuromodulation for Parkinson's disease: Proof-of-concept study
Auteurs : Ilya Adamchic [Allemagne] ; Christian Hauptmann [Allemagne] ; Utako Brigit Barnikol [Allemagne] ; Norbert Pawelczyk [Allemagne] ; Oleksandr Popovych [Allemagne] ; Thomas Theo Barnikol [Allemagne] ; Alexander Silchenko [Allemagne] ; Jens Volkmann [Allemagne] ; Günter Deuschl [Allemagne] ; Wassilios G. Meissner [France] ; Mohammad Maarouf [Allemagne] ; Volker Sturm [Allemagne] ; Hans-Joachim Freund [Allemagne] ; Peter Alexander Tass [Allemagne]Source :
- Movement Disorders [ 0885-3185 ] ; 2014.
Abstract
The discovery of abnormal synchronization of neuronal activity in the basal ganglia in Parkinson's disease (PD) has prompted the development of novel neuromodulation paradigms. Coordinated reset neuromodulation intends to specifically counteract excessive synchronization and to induce cumulative unlearning of pathological synaptic connectivity and neuronal synchrony.
In this prospective case series, six PD patients were evaluated before and after coordinated reset neuromodulation according to a standardized protocol that included both electrophysiological recordings and clinical assessments.
Coordinated reset neuromodulation of the subthalamic nucleus (STN) applied to six PD patients in an externalized setting during three stimulation days induced a significant and cumulative reduction of beta band activity that correlated with a significant improvement of motor function.
These results highlight the potential effects of coordinated reset neuromodulation of the STN in PD patients and encourage further development of this approach as an alternative to conventional high-frequency deep brain stimulation in PD. © 2014 The Authors.
Url:
DOI: 10.1002/mds.25923
PubMed: 24976001
PubMed Central: 4282372
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000785
- to stream Pmc, to step Curation: 000782
- to stream Pmc, to step Checkpoint: 000395
- to stream Ncbi, to step Merge: 001447
- to stream Ncbi, to step Curation: 001447
- to stream Ncbi, to step Checkpoint: 001447
- to stream Main, to step Merge: 000A35
- to stream Main, to step Curation: 000A24
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Coordinated reset neuromodulation for Parkinson's disease: Proof-of-concept study</title><author><name sortKey="Adamchic, Ilya" sort="Adamchic, Ilya" uniqKey="Adamchic I" first="Ilya" last="Adamchic">Ilya Adamchic</name><affiliation wicri:level="1"><nlm:aff id="au1"><institution>Institute of Neuroscience and Medicine-Neuromodulation, Jülich Research Center</institution><addr-line>Jülich, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Jülich</wicri:regionArea></affiliation></author><author><name sortKey="Hauptmann, Christian" sort="Hauptmann, Christian" uniqKey="Hauptmann C" first="Christian" last="Hauptmann">Christian Hauptmann</name><affiliation wicri:level="1"><nlm:aff id="au1"><institution>Institute of Neuroscience and Medicine-Neuromodulation, Jülich Research Center</institution><addr-line>Jülich, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Jülich</wicri:regionArea></affiliation></author><author><name sortKey="Barnikol, Utako Brigit" sort="Barnikol, Utako Brigit" uniqKey="Barnikol U" first="Utako Brigit" last="Barnikol">Utako Brigit Barnikol</name><affiliation wicri:level="1"><nlm:aff id="au1"><institution>Institute of Neuroscience and Medicine-Neuromodulation, Jülich Research Center</institution><addr-line>Jülich, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Jülich</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="au2"><institution>Department of Neuromodulation, University of Cologne</institution><addr-line>Cologne, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Cologne</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="au3"><institution>Department of Child- and Adolescent Psychiatry, University of Cologne</institution><addr-line>Cologne, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Cologne</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="au4"><institution>Clinic for Stereotactic and Functional Neurosurgery, University of Cologne</institution><addr-line>Cologne, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Cologne</wicri:regionArea></affiliation></author><author><name sortKey="Pawelczyk, Norbert" sort="Pawelczyk, Norbert" uniqKey="Pawelczyk N" first="Norbert" last="Pawelczyk">Norbert Pawelczyk</name><affiliation wicri:level="1"><nlm:aff id="au1"><institution>Institute of Neuroscience and Medicine-Neuromodulation, Jülich Research Center</institution><addr-line>Jülich, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Jülich</wicri:regionArea></affiliation></author><author><name sortKey="Popovych, Oleksandr" sort="Popovych, Oleksandr" uniqKey="Popovych O" first="Oleksandr" last="Popovych">Oleksandr Popovych</name><affiliation wicri:level="1"><nlm:aff id="au1"><institution>Institute of Neuroscience and Medicine-Neuromodulation, Jülich Research Center</institution><addr-line>Jülich, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Jülich</wicri:regionArea></affiliation></author><author><name sortKey="Barnikol, Thomas Theo" sort="Barnikol, Thomas Theo" uniqKey="Barnikol T" first="Thomas Theo" last="Barnikol">Thomas Theo Barnikol</name><affiliation wicri:level="1"><nlm:aff id="au1"><institution>Institute of Neuroscience and Medicine-Neuromodulation, Jülich Research Center</institution><addr-line>Jülich, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Jülich</wicri:regionArea></affiliation></author><author><name sortKey="Silchenko, Alexander" sort="Silchenko, Alexander" uniqKey="Silchenko A" first="Alexander" last="Silchenko">Alexander Silchenko</name><affiliation wicri:level="1"><nlm:aff id="au1"><institution>Institute of Neuroscience and Medicine-Neuromodulation, Jülich Research Center</institution><addr-line>Jülich, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Jülich</wicri:regionArea></affiliation></author><author><name sortKey="Volkmann, Jens" sort="Volkmann, Jens" uniqKey="Volkmann J" first="Jens" last="Volkmann">Jens Volkmann</name><affiliation wicri:level="1"><nlm:aff id="au5"><institution>Department of Neurology, University Würzburg</institution><addr-line>Würzburg, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Würzburg</wicri:regionArea></affiliation></author><author><name sortKey="Deuschl, Gunter" sort="Deuschl, Gunter" uniqKey="Deuschl G" first="Günter" last="Deuschl">Günter Deuschl</name><affiliation wicri:level="1"><nlm:aff id="au6"><institution>Department of Neurology, University Kiel</institution><addr-line>Kiel, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Kiel</wicri:regionArea></affiliation></author><author><name sortKey="Meissner, Wassilios G" sort="Meissner, Wassilios G" uniqKey="Meissner W" first="Wassilios G" last="Meissner">Wassilios G. Meissner</name><affiliation wicri:level="1"><nlm:aff id="au7"><institution>Institut des Maladies Neurodégénératives, Univ. de Bordeaux</institution><addr-line>Bordeaux, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Bordeaux</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="au8"><institution>CNRS Institut des Maladies Neurodégénératives</institution><addr-line>Bordeaux, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Bordeaux</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="au9"><institution>Service de Neurologie, CHU de Bordeaux</institution><addr-line>Pessac, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Pessac</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="au10"><institution>Centre de référence atrophie multisystématisée, CHU de Bordeaux</institution><addr-line>Pessac, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Pessac</wicri:regionArea></affiliation></author><author><name sortKey="Maarouf, Mohammad" sort="Maarouf, Mohammad" uniqKey="Maarouf M" first="Mohammad" last="Maarouf">Mohammad Maarouf</name><affiliation wicri:level="1"><nlm:aff id="au4"><institution>Clinic for Stereotactic and Functional Neurosurgery, University of Cologne</institution><addr-line>Cologne, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Cologne</wicri:regionArea></affiliation></author><author><name sortKey="Sturm, Volker" sort="Sturm, Volker" uniqKey="Sturm V" first="Volker" last="Sturm">Volker Sturm</name><affiliation wicri:level="1"><nlm:aff id="au4"><institution>Clinic for Stereotactic and Functional Neurosurgery, University of Cologne</institution><addr-line>Cologne, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Cologne</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="au5"><institution>Department of Neurology, University Würzburg</institution><addr-line>Würzburg, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Würzburg</wicri:regionArea></affiliation></author><author><name sortKey="Freund, Hans Joachim" sort="Freund, Hans Joachim" uniqKey="Freund H" first="Hans-Joachim" last="Freund">Hans-Joachim Freund</name><affiliation wicri:level="1"><nlm:aff id="au1"><institution>Institute of Neuroscience and Medicine-Neuromodulation, Jülich Research Center</institution><addr-line>Jülich, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Jülich</wicri:regionArea></affiliation></author><author><name sortKey="Tass, Peter Alexander" sort="Tass, Peter Alexander" uniqKey="Tass P" first="Peter Alexander" last="Tass">Peter Alexander Tass</name><affiliation wicri:level="1"><nlm:aff id="au1"><institution>Institute of Neuroscience and Medicine-Neuromodulation, Jülich Research Center</institution><addr-line>Jülich, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Jülich</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="au2"><institution>Department of Neuromodulation, University of Cologne</institution><addr-line>Cologne, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Cologne</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="au4"><institution>Clinic for Stereotactic and Functional Neurosurgery, University of Cologne</institution><addr-line>Cologne, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Cologne</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">24976001</idno><idno type="pmc">4282372</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4282372</idno><idno type="RBID">PMC:4282372</idno><idno type="doi">10.1002/mds.25923</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">000785</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000785</idno><idno type="wicri:Area/Pmc/Curation">000782</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000782</idno><idno type="wicri:Area/Pmc/Checkpoint">000395</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000395</idno><idno type="wicri:Area/Ncbi/Merge">001447</idno><idno type="wicri:Area/Ncbi/Curation">001447</idno><idno type="wicri:Area/Ncbi/Checkpoint">001447</idno><idno type="wicri:doubleKey">0885-3185:2014:Adamchic I:coordinated:reset:neuromodulation</idno><idno type="wicri:Area/Main/Merge">000A35</idno><idno type="wicri:Area/Main/Curation">000A24</idno><idno type="wicri:Area/Main/Exploration">000A24</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Coordinated reset neuromodulation for Parkinson's disease: Proof-of-concept study</title><author><name sortKey="Adamchic, Ilya" sort="Adamchic, Ilya" uniqKey="Adamchic I" first="Ilya" last="Adamchic">Ilya Adamchic</name><affiliation wicri:level="1"><nlm:aff id="au1"><institution>Institute of Neuroscience and Medicine-Neuromodulation, Jülich Research Center</institution><addr-line>Jülich, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Jülich</wicri:regionArea></affiliation></author><author><name sortKey="Hauptmann, Christian" sort="Hauptmann, Christian" uniqKey="Hauptmann C" first="Christian" last="Hauptmann">Christian Hauptmann</name><affiliation wicri:level="1"><nlm:aff id="au1"><institution>Institute of Neuroscience and Medicine-Neuromodulation, Jülich Research Center</institution><addr-line>Jülich, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Jülich</wicri:regionArea></affiliation></author><author><name sortKey="Barnikol, Utako Brigit" sort="Barnikol, Utako Brigit" uniqKey="Barnikol U" first="Utako Brigit" last="Barnikol">Utako Brigit Barnikol</name><affiliation wicri:level="1"><nlm:aff id="au1"><institution>Institute of Neuroscience and Medicine-Neuromodulation, Jülich Research Center</institution><addr-line>Jülich, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Jülich</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="au2"><institution>Department of Neuromodulation, University of Cologne</institution><addr-line>Cologne, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Cologne</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="au3"><institution>Department of Child- and Adolescent Psychiatry, University of Cologne</institution><addr-line>Cologne, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Cologne</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="au4"><institution>Clinic for Stereotactic and Functional Neurosurgery, University of Cologne</institution><addr-line>Cologne, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Cologne</wicri:regionArea></affiliation></author><author><name sortKey="Pawelczyk, Norbert" sort="Pawelczyk, Norbert" uniqKey="Pawelczyk N" first="Norbert" last="Pawelczyk">Norbert Pawelczyk</name><affiliation wicri:level="1"><nlm:aff id="au1"><institution>Institute of Neuroscience and Medicine-Neuromodulation, Jülich Research Center</institution><addr-line>Jülich, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Jülich</wicri:regionArea></affiliation></author><author><name sortKey="Popovych, Oleksandr" sort="Popovych, Oleksandr" uniqKey="Popovych O" first="Oleksandr" last="Popovych">Oleksandr Popovych</name><affiliation wicri:level="1"><nlm:aff id="au1"><institution>Institute of Neuroscience and Medicine-Neuromodulation, Jülich Research Center</institution><addr-line>Jülich, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Jülich</wicri:regionArea></affiliation></author><author><name sortKey="Barnikol, Thomas Theo" sort="Barnikol, Thomas Theo" uniqKey="Barnikol T" first="Thomas Theo" last="Barnikol">Thomas Theo Barnikol</name><affiliation wicri:level="1"><nlm:aff id="au1"><institution>Institute of Neuroscience and Medicine-Neuromodulation, Jülich Research Center</institution><addr-line>Jülich, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Jülich</wicri:regionArea></affiliation></author><author><name sortKey="Silchenko, Alexander" sort="Silchenko, Alexander" uniqKey="Silchenko A" first="Alexander" last="Silchenko">Alexander Silchenko</name><affiliation wicri:level="1"><nlm:aff id="au1"><institution>Institute of Neuroscience and Medicine-Neuromodulation, Jülich Research Center</institution><addr-line>Jülich, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Jülich</wicri:regionArea></affiliation></author><author><name sortKey="Volkmann, Jens" sort="Volkmann, Jens" uniqKey="Volkmann J" first="Jens" last="Volkmann">Jens Volkmann</name><affiliation wicri:level="1"><nlm:aff id="au5"><institution>Department of Neurology, University Würzburg</institution><addr-line>Würzburg, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Würzburg</wicri:regionArea></affiliation></author><author><name sortKey="Deuschl, Gunter" sort="Deuschl, Gunter" uniqKey="Deuschl G" first="Günter" last="Deuschl">Günter Deuschl</name><affiliation wicri:level="1"><nlm:aff id="au6"><institution>Department of Neurology, University Kiel</institution><addr-line>Kiel, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Kiel</wicri:regionArea></affiliation></author><author><name sortKey="Meissner, Wassilios G" sort="Meissner, Wassilios G" uniqKey="Meissner W" first="Wassilios G" last="Meissner">Wassilios G. Meissner</name><affiliation wicri:level="1"><nlm:aff id="au7"><institution>Institut des Maladies Neurodégénératives, Univ. de Bordeaux</institution><addr-line>Bordeaux, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Bordeaux</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="au8"><institution>CNRS Institut des Maladies Neurodégénératives</institution><addr-line>Bordeaux, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Bordeaux</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="au9"><institution>Service de Neurologie, CHU de Bordeaux</institution><addr-line>Pessac, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Pessac</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="au10"><institution>Centre de référence atrophie multisystématisée, CHU de Bordeaux</institution><addr-line>Pessac, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Pessac</wicri:regionArea></affiliation></author><author><name sortKey="Maarouf, Mohammad" sort="Maarouf, Mohammad" uniqKey="Maarouf M" first="Mohammad" last="Maarouf">Mohammad Maarouf</name><affiliation wicri:level="1"><nlm:aff id="au4"><institution>Clinic for Stereotactic and Functional Neurosurgery, University of Cologne</institution><addr-line>Cologne, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Cologne</wicri:regionArea></affiliation></author><author><name sortKey="Sturm, Volker" sort="Sturm, Volker" uniqKey="Sturm V" first="Volker" last="Sturm">Volker Sturm</name><affiliation wicri:level="1"><nlm:aff id="au4"><institution>Clinic for Stereotactic and Functional Neurosurgery, University of Cologne</institution><addr-line>Cologne, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Cologne</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="au5"><institution>Department of Neurology, University Würzburg</institution><addr-line>Würzburg, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Würzburg</wicri:regionArea></affiliation></author><author><name sortKey="Freund, Hans Joachim" sort="Freund, Hans Joachim" uniqKey="Freund H" first="Hans-Joachim" last="Freund">Hans-Joachim Freund</name><affiliation wicri:level="1"><nlm:aff id="au1"><institution>Institute of Neuroscience and Medicine-Neuromodulation, Jülich Research Center</institution><addr-line>Jülich, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Jülich</wicri:regionArea></affiliation></author><author><name sortKey="Tass, Peter Alexander" sort="Tass, Peter Alexander" uniqKey="Tass P" first="Peter Alexander" last="Tass">Peter Alexander Tass</name><affiliation wicri:level="1"><nlm:aff id="au1"><institution>Institute of Neuroscience and Medicine-Neuromodulation, Jülich Research Center</institution><addr-line>Jülich, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Jülich</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="au2"><institution>Department of Neuromodulation, University of Cologne</institution><addr-line>Cologne, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Cologne</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="au4"><institution>Clinic for Stereotactic and Functional Neurosurgery, University of Cologne</institution><addr-line>Cologne, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Cologne</wicri:regionArea></affiliation></author></analytic><series><title level="j">Movement Disorders</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>The discovery of abnormal synchronization of neuronal activity in the basal ganglia in Parkinson's disease (PD) has prompted the development of novel neuromodulation paradigms. Coordinated reset neuromodulation intends to specifically counteract excessive synchronization and to induce cumulative unlearning of pathological synaptic connectivity and neuronal synchrony.</p></sec><sec><title>Methods</title><p>In this prospective case series, six PD patients were evaluated before and after coordinated reset neuromodulation according to a standardized protocol that included both electrophysiological recordings and clinical assessments.</p></sec><sec><title>Results</title><p>Coordinated reset neuromodulation of the subthalamic nucleus (STN) applied to six PD patients in an externalized setting during three stimulation days induced a significant and cumulative reduction of beta band activity that correlated with a significant improvement of motor function.</p></sec><sec><title>Conclusions</title><p>These results highlight the potential effects of coordinated reset neuromodulation of the STN in PD patients and encourage further development of this approach as an alternative to conventional high-frequency deep brain stimulation in PD. © 2014 The Authors. <italic>Movement</italic> Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Deuschl, G" uniqKey="Deuschl G">G Deuschl</name></author><author><name sortKey="Schade Brittinger, C" uniqKey="Schade Brittinger C">C Schade-Brittinger</name></author><author><name sortKey="Krack, P" uniqKey="Krack P">P Krack</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Volkmann, J" uniqKey="Volkmann J">J Volkmann</name></author><author><name sortKey="Moro, E" uniqKey="Moro E">E Moro</name></author><author><name sortKey="Pahwa, R" uniqKey="Pahwa R">R Pahwa</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rosin, B" uniqKey="Rosin B">B Rosin</name></author><author><name sortKey="Slovik, M" uniqKey="Slovik M">M Slovik</name></author><author><name sortKey="Mitelman, R" uniqKey="Mitelman R">R Mitelman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Little, S" uniqKey="Little S">S Little</name></author><author><name sortKey="Pogosyan, A" uniqKey="Pogosyan A">A Pogosyan</name></author><author><name sortKey="Neal, S" uniqKey="Neal S">S Neal</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tass, Pa" uniqKey="Tass P">PA Tass</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tass, Pa" uniqKey="Tass P">PA Tass</name></author><author><name sortKey="Majtanik, M" uniqKey="Majtanik M">M Majtanik</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hammond, C" uniqKey="Hammond C">C Hammond</name></author><author><name sortKey="Bergman, H" uniqKey="Bergman H">H Bergman</name></author><author><name sortKey="Brown, P" uniqKey="Brown P">P Brown</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kuhn, Aa" uniqKey="Kuhn A">AA Kühn</name></author><author><name sortKey="Kempf, F" uniqKey="Kempf F">F Kempf</name></author><author><name sortKey="Bruuecke, C" uniqKey="Bruuecke C">C Bruuecke</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tass, Pa" uniqKey="Tass P">PA Tass</name></author><author><name sortKey="Silchenko, An" uniqKey="Silchenko A">AN Silchenko</name></author><author><name sortKey="Hauptmann, C" uniqKey="Hauptmann C">C Hauptmann</name></author><author><name sortKey="Barnikol, Ub" uniqKey="Barnikol U">UB Barnikol</name></author><author><name sortKey="Speckmann, Ej" uniqKey="Speckmann E">EJ Speckmann</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tass, Pa" uniqKey="Tass P">PA Tass</name></author><author><name sortKey="Qin, L" uniqKey="Qin L">L Qin</name></author><author><name sortKey="Hauptmann, C" uniqKey="Hauptmann C">C Hauptmann</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Meissner, W" uniqKey="Meissner W">W Meissner</name></author><author><name sortKey="Leblois, A" uniqKey="Leblois A">A Leblois</name></author><author><name sortKey="Hansel, D" uniqKey="Hansel D">D Hansel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fahn, S" uniqKey="Fahn S">S Fahn</name></author><author><name sortKey="Elton, Rl" uniqKey="Elton R">RL Elton</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hauptmann, C" uniqKey="Hauptmann C">C Hauptmann</name></author><author><name sortKey="Roulet, Jc" uniqKey="Roulet J">JC Roulet</name></author><author><name sortKey="Niederhauser, Jj" uniqKey="Niederhauser J">JJ Niederhauser</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tass, Pa" uniqKey="Tass P">PA Tass</name></author><author><name sortKey="Smirnov, D" uniqKey="Smirnov D">D Smirnov</name></author><author><name sortKey="Karavaev, A" uniqKey="Karavaev A">A Karavaev</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Allemagne</li><li>France</li></country></list><tree><country name="Allemagne"><noRegion><name sortKey="Adamchic, Ilya" sort="Adamchic, Ilya" uniqKey="Adamchic I" first="Ilya" last="Adamchic">Ilya Adamchic</name></noRegion><name sortKey="Barnikol, Thomas Theo" sort="Barnikol, Thomas Theo" uniqKey="Barnikol T" first="Thomas Theo" last="Barnikol">Thomas Theo Barnikol</name><name sortKey="Barnikol, Utako Brigit" sort="Barnikol, Utako Brigit" uniqKey="Barnikol U" first="Utako Brigit" last="Barnikol">Utako Brigit Barnikol</name><name sortKey="Barnikol, Utako Brigit" sort="Barnikol, Utako Brigit" uniqKey="Barnikol U" first="Utako Brigit" last="Barnikol">Utako Brigit Barnikol</name><name sortKey="Barnikol, Utako Brigit" sort="Barnikol, Utako Brigit" uniqKey="Barnikol U" first="Utako Brigit" last="Barnikol">Utako Brigit Barnikol</name><name sortKey="Barnikol, Utako Brigit" sort="Barnikol, Utako Brigit" uniqKey="Barnikol U" first="Utako Brigit" last="Barnikol">Utako Brigit Barnikol</name><name sortKey="Deuschl, Gunter" sort="Deuschl, Gunter" uniqKey="Deuschl G" first="Günter" last="Deuschl">Günter Deuschl</name><name sortKey="Freund, Hans Joachim" sort="Freund, Hans Joachim" uniqKey="Freund H" first="Hans-Joachim" last="Freund">Hans-Joachim Freund</name><name sortKey="Hauptmann, Christian" sort="Hauptmann, Christian" uniqKey="Hauptmann C" first="Christian" last="Hauptmann">Christian Hauptmann</name><name sortKey="Maarouf, Mohammad" sort="Maarouf, Mohammad" uniqKey="Maarouf M" first="Mohammad" last="Maarouf">Mohammad Maarouf</name><name sortKey="Pawelczyk, Norbert" sort="Pawelczyk, Norbert" uniqKey="Pawelczyk N" first="Norbert" last="Pawelczyk">Norbert Pawelczyk</name><name sortKey="Popovych, Oleksandr" sort="Popovych, Oleksandr" uniqKey="Popovych O" first="Oleksandr" last="Popovych">Oleksandr Popovych</name><name sortKey="Silchenko, Alexander" sort="Silchenko, Alexander" uniqKey="Silchenko A" first="Alexander" last="Silchenko">Alexander Silchenko</name><name sortKey="Sturm, Volker" sort="Sturm, Volker" uniqKey="Sturm V" first="Volker" last="Sturm">Volker Sturm</name><name sortKey="Sturm, Volker" sort="Sturm, Volker" uniqKey="Sturm V" first="Volker" last="Sturm">Volker Sturm</name><name sortKey="Tass, Peter Alexander" sort="Tass, Peter Alexander" uniqKey="Tass P" first="Peter Alexander" last="Tass">Peter Alexander Tass</name><name sortKey="Tass, Peter Alexander" sort="Tass, Peter Alexander" uniqKey="Tass P" first="Peter Alexander" last="Tass">Peter Alexander Tass</name><name sortKey="Tass, Peter Alexander" sort="Tass, Peter Alexander" uniqKey="Tass P" first="Peter Alexander" last="Tass">Peter Alexander Tass</name><name sortKey="Volkmann, Jens" sort="Volkmann, Jens" uniqKey="Volkmann J" first="Jens" last="Volkmann">Jens Volkmann</name></country><country name="France"><noRegion><name sortKey="Meissner, Wassilios G" sort="Meissner, Wassilios G" uniqKey="Meissner W" first="Wassilios G" last="Meissner">Wassilios G. Meissner</name></noRegion><name sortKey="Meissner, Wassilios G" sort="Meissner, Wassilios G" uniqKey="Meissner W" first="Wassilios G" last="Meissner">Wassilios G. Meissner</name><name sortKey="Meissner, Wassilios G" sort="Meissner, Wassilios G" uniqKey="Meissner W" first="Wassilios G" last="Meissner">Wassilios G. Meissner</name><name sortKey="Meissner, Wassilios G" sort="Meissner, Wassilios G" uniqKey="Meissner W" first="Wassilios G" last="Meissner">Wassilios G. Meissner</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonFranceV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000A24 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000A24 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= ParkinsonFranceV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= PMC:4282372
|texte= Coordinated reset neuromodulation for Parkinson's disease: Proof-of-concept study
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:24976001" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a ParkinsonFranceV1
| This area was generated with Dilib version V0.6.29. |  |